Rhodopsin Signaling and Organization in Heterozygote Rhodopsin Knockout Mice
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چکیده
منابع مشابه
Rhodopsin signaling and organization in heterozygote rhodopsin knockout mice.
Rhodopsin (Rho) resides within internal membrane structures called disc membranes that are found in the rod outer segments (ROS) of photoreceptors in the retina. Rho expression is essential for formation of ROS, which are absent in knockout Rho-/- mice. ROS of mice heterozygous for the Rho gene deletion (Rho+/-) may have a lower Rho density than wild type (WT) membranes, or the ROS structure ma...
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reducing power of steroids. The low pH of the reagent, which is responsible for hydrolysis of the cellulose, cannot be raised materially without seriously affecting the sensitivity. The latter depends on the formation of the yellow arsenomolybdate complex which requires a large excess of acid. In the experience of the author, variations of the blank value and serious disagreement between duplic...
متن کاملRhodopsin 7–The unusual Rhodopsin in Drosophila
Rhodopsins are the major photopigments in the fruit fly Drosophila melanogaster. Drosophila express six well-characterized Rhodopsins (Rh1-Rh6) with distinct absorption maxima and expression pattern. In 2000, when the Drosophila genome was published, a novel Rhodopsin gene was discovered: Rhodopsin 7 (Rh7). Rh7 is highly conserved among the Drosophila genus and is also found in other arthropods...
متن کاملRhodopsin accumulation at abnormal sites in retinas of mice with a human P23H rhodopsin transgene.
PURPOSE To investigate the mechanism by which photoreceptors degenerate in transgenic mice carrying a mutant human rhodopsin gene (P23H). METHODS The temporal and spatial pattern of the retinal degeneration caused by P23H rhodopsin was mapped using immunocytochemistry with rhodopsin-specific antibodies. The subcellular localizations of rhodopsin, transducin, and rod cGMP phosphodiesterase (PD...
متن کاملBathorhodopsin intermediates from 11-cis-rhodopsin and 9-cis-rhodopsin.
Bathorhodopsin-rhodopsin difference spectra of native 11-cis-rhodopsin and regenerated 9-cis-rhodopsin were measured at room temperature with a double-beam laser spectrophotometer after excitation at 532 nm. A detailed analysis of data obtained at 85 psec after excitation suggests that the bathorhodopsins generated from 11-cis- and 9-cis-rhodopsin differ in their extinction coefficients and tha...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2004
ISSN: 0021-9258
DOI: 10.1074/jbc.m408362200